• As Table shows all guidelines recommend OACs

  2019-05-31

  

  As Table 2 shows, all guidelines recommend OACs for patients with a CHADS2 score of ≥2, whereas recommendations for low-risk patients with a CHADS2 score of 0/1 differ slightly across guidelines. Evidence indicating that novel OACs decrease the risk of ICH by half as compared with warfarin has affec

• The main products of EBM are evidence based guidelines

  2019-05-31

  

  The main products of EBM are evidence-based guidelines (EBGs), “systematically developed statements to assist practitioner and patient decision about appropriate health care for specific clinical circumstances” [21]. EBGs indeed substantially improve clinical care [29]. Preliminary steps for guidel

• Bone marrow resident Macs Osteomacs are located

  2019-05-31

  

  Bone marrow resident Macs (Osteomacs) are located in canopy-like structures in endosteal and periosteal surfaces, above osteoblasts [6]; osteoclasts result from the fusion of several myeloid osteoclast precursors [7]. Osteomacs constitute approximately 17% of the bone marrow salvinorin a and they d

• At the mechanistic level our results strongly

  2019-05-31

  

  At the mechanistic level, our results strongly suggested that the cholestatic protective effect of STS was most likely accounted for by the activation of LXR, a nuclear receptor known for its anti-cholestatic activity. The activation of LXR was supported by the induction of typical LXR target genes,

• En conclusi n vivir bien buen vivir no son

  2019-05-30

  

  En conclusión, vivir bien/buen vivir no son por el momento nuevos paradigmas, pese a que, por ejemplo, los autores del Plan Nacional para el Buen Vivir de Ecuador (2009-2013) se referan a una transición del concepto de desarrollo al buen vivir en los términos de un “cambio de para-digma”. En estos t

• La cr tica realizada al

  2019-05-30

  

  La crítica realizada al ccpor las diferentes comisiones develó la verticalidad en la toma de decisiones políticas, las cuales se agudizaban cuando se realizaban acciones militares, lo que ocasionó constantes fricciones y sanciones (S)-Crizotinib algunos miembros de la Comisión Militar o de las diver

• think about them. br We recently reported associations betwe

  2019-05-30

  

  We recently reported associations between maternal age at childbirth and outcomes in the offspring, using data from five birth cohorts (COHORTS collaboration) in low-income and middle-income countries (LMICs), in . Young maternal age ( Antimicrobial resistance is recognised as a serious global he

• Introduction The assessment of hormonal receptor HR and

  2019-05-30

  

  Introduction The assessment of hormonal receptor (HR) and human epidermal growth factor receptor-2 (HER2) status by immunohistochemistry (IHC) groups breast cancer into three major subtypes: 1) luminal-like subtype (HR positive/HER2 negative); 2) HER2 subtype (HER2 positive and HR negative/positive

• br Conflict of interest br

  2019-05-30

  

  Conflict of interest Introduction For decades, cancer has been the leading cause of death in Taiwan. In 2012, esophageal cancer was the eighth most common cancer globally, with 456,000 new cases presenting that year. Esophageal cancer caused approximately 400,000 deaths in 2012, up from 345,00

• El t tulo del poema define una intertextualidad que

  2019-05-30

  

  El título del poema define una intertextualidad que se refuerza tipográficamente por medio de las cursivas del primer verso. La diferencia gráfica entre las palabras que integran este verso resalta el signo de la negación —el adverbio “no”— expresando una contradicción que culmina en los dos versos

• Ciertamente Espa a era poco

  2019-05-30

  

  Ciertamente, España era poco y mal conocida. Y ello no sólo ocurría con los radicales europeos, sino también con los latinoamericanos. Creo que la actividad intelectual de La Sagra puede ayudar fructose 1 6 bisphosphatase comprender por qué el joven Bilbao que regresa en 1850 del exilio francés ya n

• Los tres especialistas invitan a volver la mirada hacia

  2019-05-30

  

  Los tres especialistas invitan a volver la mirada hacia la figura polémica de Las Casas y su Brevíssima relación desde nuestro complejo presente, para interpelarnos como lectores críticos del siglo xxi acerca de la dolorosa historia cysteine protease inhibitor de América Latina. Cronista que “ve

• En realidad el texto con el que Granada concluye su

  2019-05-29

  

  En realidad el texto, con el que Granada concluye su Introducción al Símbolo de la Fé, consta de diez capítulos en los que se insiste en no explicar Sildenafil mesylate los que quieran convertirse de manera inmediata “los misterios del cristianismo, porque no creen aún, sino que hay que llevarlos po

• Assim a decis o de avan ar sobre

  2019-05-29

  

  Assim, ruthenium red decisão de avançar sobre Lima deve ser entendida antes como uma “fuga para frente” do que como desdobramento de um crescimento orgânico. Mas em seu momento, havia um genuíno receio em relação ao poder insurgente, já que a repercussão das ações senderistas na capital era amplific

• br Conclusion br Authors contribution br Competing

  2019-05-29

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

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