• Gene chip is a detection technique that can detect

  2020-12-28

  

  Gene chip is a detection technique that can detect all the time-point differentially expressed genes (DEGs) information within the same sample. However, due to sample heterogeneity or different sequencing platform, the results for the expressed mRNAs are inconsistent with different gene profile. The

• The BMP family comprises significant growth factors for the

  2020-12-28

  

  The BMP family comprises significant growth factors for the regeneration of bone and cartilage. Among these, BMP- has been known as an early marker during the proliferation of osteoblast cells, and one of the most potent stimulators of osteoblastic cells differentiation [40]. Studies with COX-2 knoc

• DUBs are involved in cell cycle regulation and DNA damage

  2020-12-28

  

  DUBs are involved in with regulation and DNA damage pathways and since, in cancer and different stress conditions all the proteins which regulate cell cycle and DNA damage/repair are either up/down regulated (Singh et al., 2013, Singh et al., 2011, Kumar and de Massy, 2010, Gupta et al., 2010), it

• br Results br Discussion The structures presented here were

  2020-12-28

  

  Results Discussion The structures presented here were solved at high Fluticasone propionate and show in detail how DDR1 achieves high affinity for imatinib and ponatinib, respectively. Both type II inhibitors bind in their more potent extended conformations to the inactive DFG-out conformatio

• Pyrazolopyrimidines are bioisostere of purine exhibit promis

  2020-12-28

  

  Pyrazolopyrimidines are bioisostere of purine exhibit promising antitumor activity by competitively binding to the ATP active site of different kinase EMD638683 receptor [16,17]. Several compounds of this family were found to induce apoptosis and/or reduce cell proliferation in various solid tumour

• br Materials and Methods br

  2020-12-28

  

  Materials and Methods Results Discussion Mitochondrion not only generates energy but also produces ROS under physiological conditions. However, overnutrition causes mitochondrial congestion and elicits excessive ROS generation, leading to insulin resistance (Muoio, 2014, Houstis et al., 200

• ClC is a member of the voltage gated

  2020-12-28

  

  ClC-3 is a member of the voltage-gated chloride channel superfamily and has many roles in cell proliferation, apoptosis, pfk progression and so on (Dai et al., 2005). A growing number of studies showed that ClC-3 encoded a volume-regulated Cl− channel (ICl,Vol) in heart, that could contribute to the

• Ligand independent activation of neuronal nuclear estrogen r

  2020-12-28

  

  Ligand-independent activation of neuronal nuclear estrogen receptors may also continue to occur in absence of ovarian estrogens. AF-1 requires intracellular kinase cascade-dependent phosphorylation of specific residues in the A/B domain of nuclear estrogen receptors (Le Goff et al., 1994; Kato et al

• PF-431396 mg Introduction Penetrator with Enhanced Lateral E

  2020-12-28

  

  Introduction Penetrator with Enhanced Lateral Effect (PELE) is a kind of ammunition which consists of a low-density material as the filling and a high-density material as the jacket [1,2]. When PELE impact target, the jacket is radially accelerated, expanded and fractured because of distinctive lat

• br Results br Discussion Fetal development

  2020-12-28

  

  Results Discussion Fetal development occurs under conditions of low oxygen tension and steady maternal glucose such that physiologic systems including the pancreas are functionally poised in the prenatal state. Postnatally, oxidative metabolism becomes dominant and intermittent feeding exposes

• So far several important flovonoids and polyphenoilc compoun

  2020-12-28

  

  So far, several important flovonoids and polyphenoilc compounds were subjected to various human studies regarding their potential therapeutic and adverse effects (Ide et al., 2014; Turner et al., 2015; Witte et al., 2014) (Table 1). Resveratrol (trans-3,4, 5-trihydroxystilbene) is widespread stilbe

• In conclusion BmSpry was targeted by three viruses

  2020-12-28

  

  In conclusion, BmSpry was targeted by three viruses to regulate the ERK pathway and thus ensure viral reproduction in the silkworm. This is the first report regarding a general mechanism of host regulation by multiple silkworm viruses, and this can pave the way for future virus control in other inse

• Conventional aromatic radiofluorination via nucleophilic sub

  2020-12-26

  

  Conventional aromatic radiofluorination via nucleophilic substitution requires electron-withdrawing activating group(s) at the ortho or para position to achieve good radiolabeling yield. In the case of CJ-042794 (), the phenoxy substitution para to the fluoro group is considered an electro-donating

• In rodents Wang et al

  2020-12-26

  

  In rodents (Wang et al., 2003, Wang and Tsirka, 2005b, Zhu et al., 2012) and humans (Wang et al., 2011), the major forms of cell death after ICH are necrosis and apoptosis. In the perihematomal region of rodents, the number of necrotic and apoptotic cells peaks at 72h post-ICH (Matsushita et al., 20

• DDR although normally expressed in

  2020-12-26

  

  DDR2, although normally expressed in Auranofin with mesenchymal features, has also been reported to enhance EMT. In A549 lung cancer cells, TGFβ1 increases the expression of type I collagen and DDR2. Knocking-down COL1A1 or DDR2 with siRNA is sufficient to inhibit EMT and cell migration induced by

16411 records 751/1095 page Previous Next First page 上5页 751752753754755 下5页 Last page