• In summary the loss of seven Cyp a genes

  2020-08-10

  

  In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to

• The data presented above clearly

  2020-08-10

  

  The data presented above clearly indicate an important role of eIF4E for the nucleocytoplasmic transport of the human iNOS mRNA. To analyze the sequence elements of the iNOS mRNA that are important for this eIF4E-mediated transport we performed transient transfection experiments using constructs con

• We thank Dr Hongqiang Qin

  2020-08-10

  

  We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr

• br Proposed methodology At the outset the wind

  2020-08-10

  

  Proposed methodology At the outset, the wind power outputs must be obtained which are to be included in the OPF model. This work utilizes a modified version of the simulation method. Rather than using the simulated wind power values for each hour of the year, the probability of each wind power in

• Elevated homocysteine has been considered to be a risk

  2020-08-10

  

  Elevated homocysteine has been considered to be a risk factor for vascular dysfunction, vascular disease, and preeclampsia , . The methionine-homocysteine metabolism is responsible for supplying COMT with the methyl-group donor (-adenosyl methionine; SAM) necessary for 2-ME synthesis, and alteration

• Altogether the results of this study demonstrate that periph

  2020-08-10

  

  Altogether, the results of this study demonstrate that peripheral blockade of both ETA and ETB receptors reduces tumor-induced facial heat hyperalgesia and increased spontaneous grooming, without modifying ongoing nociception. It is possible to suggest that bosentan is acting upon both receptors pre

• Another layer of CK regulation in

  2020-08-08

  

  Another layer of CK1 regulation in the Hh and Wnt pathways is to employ different CK1 isoforms to phosphorylate distinct pathway components or even distinct sites on the same substrates. In this regard, it has been shown recently that the membrane-associated CK1 isoform CK1γ, but not the cytosolic i

• br Conclusions br Statement of

  2020-08-08

  

  Conclusions Statement of authorship Nonaneurysmal subarachnoid hemorrhage (NA-SAH) differs from aneurysmal subarachnoid hemorrhage (SAH) in both clinical course and outcome. In spite of many reports and case series since the first description in 1985, the etiology of NA-SAH remains uncertain

• br Discussion br Concluding remarks br Acknowledgments The

  2020-08-08

  

  Discussion Concluding remarks Acknowledgments The current study was supported by the Discovery grant from Natural Science and Technology Research Council of Canada (NSERC, RFN.356021) and by Louise and Alan Edwards Foundation Grant in Pain Research (RFN.68772) to Weiya Ma. This study has no

• br Conclusion The past few years have witnessed substantial

  2020-08-08

  

  Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte

• Postmenopausal women have increased susceptibility for devel

  2020-08-06

  

  Postmenopausal women have increased susceptibility for developing obesity and chronic inflammation. One hypothesis is that, in women, the hormonal withdrawal during this critical period might account for augmented incidence of inflammatory conditions that may increase the risk of developing CNS path

• br Introduction Autosomal dominant polycystic kidney disease

  2020-08-06

  

  Introduction Autosomal-dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that affects 600,000 Americans and 12.5 million people worldwide and accounts for 5% of kidney dialysis and transplant patients (http://www.pkdcure.org). This disease is characterized by the formatio

• Components of the ET system are

  2020-08-06

  

  Components of the ET system are expressed in the retina (Chakravarthy et al., 1997; McDonald et al., 2010) including in patients with proliferative DR (Adamiec-Mroczek et al., 2010; Roldan-Pallares et al., 2005). However, whether individual antagonism of the ETRA and ETRB influence the development o

• For the small series of substituted

  2020-08-06

  

  For the small series of 4-substituted biphenyl-3-ylchromenones evaluated (–), it is evident that substitution did not improve activity, and with the exception of the 4-hydroxy derivative (), which proved to be equipotent with the biphenyl-3-ylchromenone (), a 5- to 10-fold WAY-100635 maleate salt i

• The DDR gene is located in q and

  2020-08-06

  

  The DDR2 gene is located in 1q23.3, and its product is a tyrosine kinase receptor for fibrillar collagen [7], [8], [9], [10]. Under normal physiological conditions, it acts in cutaneous wound healing mediated by proliferation, chemotactic migration, and secretion of metalloproteinases and collagen b

15844 records 784/1057 page Previous Next First page 上5页 781782783784785 下5页 Last page