In conclusion our data highlight that variable anti oxidativ

In conclusion, our data highlight that variable anti-oxidative 3 bromopyruvate could be released through peptic hydrolysis of CMP fractions. Although casein hydrolysates produced a larger number of peptides (Table 1) with variable antioxidant capacities, all the peptides from whey hydrolysate exhibited higher superoxide scavenging potencies (Fig. 5) than those from caseins (Fig. 6). But casein peptides particularly in peak 1 (P1) were more efficient in reducing DPPH than those from the whey (Fig. 7). The amphiphilic characteristics of peptides of CMP seem to be important for the observed antioxidant potency, most likely as they enhance the solubility of the peptides and participate in protons exchange with radical species. Our study found that peptides from both caseins and whey hydrolysates exhibited remarkable protective effects on H2O2-stressed yeast cells (Fig. 8). Although other proteases could be effective, the peptides generated by pepsin from camel milk caseins and whey proteins could be excellent candidates for the development of novel therapeutic peptides for the treatment of oxidative stress and the associated diseases.