Archives

  • 2018-07
  • 2018-10
  • 2018-11
  • 2019-04
  • 2019-05
  • 2019-06
  • 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2019-12
  • 2020-01
  • 2020-02
  • 2020-03
  • 2020-04
  • 2020-05
  • 2020-06
  • 2020-07
  • 2020-08
  • 2020-09
  • 2020-10
  • 2020-11
  • 2020-12
  • 2021-01
  • 2021-02
  • 2021-03
  • 2021-04
  • 2021-05
  • 2021-06
  • 2021-07
  • 2021-08
  • 2021-09
  • 2021-10
  • 2021-11
  • 2021-12
  • 2022-01
  • 2022-02
  • 2022-03
  • 2022-04
  • 2022-05
  • 2022-06
  • 2022-07
  • 2022-08
  • 2022-09
  • 2022-10
  • 2022-11
  • 2022-12
  • 2023-01
  • 2023-02
  • 2023-03
  • 2023-04
  • 2023-05
  • 2023-06
  • 2023-07
  • 2023-08
  • 2023-09
  • 2023-10
  • 2023-11
  • 2023-12
  • 2024-01
  • 2024-02
  • 2024-03
  • Lung cancer is the most common

    2018-10-30

    Lung cancer is the most common cancer in US and worldwide (Centers for Disease Control and Prevention and National Center for Health Statistics, 2013; American Cancer Society, 2014), and the survival rate is low (Howlader et al., 2013). Most cases (90%) of lung cancer are attributable to smoking (General, 2014). We demonstrate that quitting smoking is highly beneficial in reducing lung cancer risks for smokers regardless of their CHRNA5 rs16969968 genetic risk status. Evidence suggest that relative to individuals with CHRNA5 rs16969968 low-risk genotypes, those with high-risk genotypes are likely to smoke greater quantities, inhale more deeply, have more difficulty quitting, and have higher risk for lung cancer (Bierut et al., 2007; Saccone et al., 2010; TAG, 2010; Thorgeirsson et al., 2010; Thorgeirsson et al., 2008; Chen et al., 2012; Chen DZNep et al., 2015a; Hung et al., 2008a; Bloom et al., 2014). We now extend this evidence to show that quitting smoking produces essentially equivalent benefit regardless of DZNep for this genetic risk factor. These results have potential value for preventive counseling with smokers; smokers with high-risk CHRNA5 genotypes can be informed that, on average, smokers with their genetic risk can largely eliminate their elevated genetic risk for lung cancer by quitting smoking. They can cut their risk of lung cancer in half and delay its onset by 7years, if they develop it. These results underscore the potential value of smoking cessation for all smokers, they elucidate the causal path from CHRNA5 risk to lung cancer diagnosis, and they have potential value for framing preventive interventions for those who smoke.
    Funding International Lung Cancer Consortium (ILCCO): The data management of ILCCO is supported by Cancer Care Ontario Research Chair awarded to R. Hung, and NIH U19 CA148127. Transdisciplinary Research in Cancer of the Lung (TRICL). The TRICL study was supported by a grant from the National Institute of Health (U19CA148127). The Toronto study was also supported by Canadian Cancer Society Research Institute (no.020214), Ontario Institute of Cancer and Cancer Care Ontario Chair Award to RH. For the German Lung Cancer Study, funding for MD Anderson Cancer Study was provided by NIH grants (P50 CA70907, R01CA121197, R01 CA127219, U19CA148127, R01CA55769) and CPRIT grant (RP100443). The Harvard Lung Cancer Study was funded by the National Institutes of Health (CA074386, CA092824, CA090578. The National Key Basic Research Program Grant was funded by (2011CB503805) and the National Natural Science Foundation of China (30730080, 30972541, 30901233 and 30872178). MD Anderson was funded by NCI/NIH K07CA160753. German Lung Cancer Study (Germany). Germany Saarland ESTHER Study. This study was supported in part by the Baden-Württemberg State Ministry of Science, Research and Arts; by the German Federal Ministry of Education and Research. Greater Toronto Area Lung Cancer study: This study was supported by Canadian Cancer Society Research Institute (no. 020,214) to R. Hung. Hawaii Case-Control Study: This project was supported by Grant ROI-CA-55874 and Contract NOI-CN-05,223 from the United States National Cancer Institute and by Grant EDT-78 from the American Cancer Society. Karmanos Cancer Institute, Wayne State University: The Karmanos Cancer Institute contribution was supported by the National Institutes of Health (NIH) (R01CA60691, R01CA87895, N01PC35145, P30CA022453). Mayo Study, Mayo Clinic, College of Medicine: The contribution was supported by NIH-R01–80127/84354 and Mayo Foundation Fund. NELCS: The New England Lung Cancer Study was funded by Grant Number P20RR018787 from the National Center for Research Resources (NCRR), a nephron component of the National Institutes of Health (NIH). Netherlands Radboudumc: The study was funded by an investment grant of Radboud university medical center. Northern California Lung Cancer Study, University of California San Francisco (UCSF):