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Kuda et al reported that the activity of
2024-04-09
Kuda et al. (1997) reported that the activity of aminopeptidase A (ApA) but not aminopeptidase B (ApB) nor aminopeptidase N (ApN) was decreased in plasma from patients with Alzheimer's disease (AD). More recently Puertas et al. (2013) reported that the activities of plasma ApA, ApB, ApN and IRAP wer
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The amino acids evaluated in this study
2024-04-09
The amino acids evaluated in this study represent proteinogenic (amino acids that are applied in the genetic code) or even essential ones (amino acids that cannot be synthesised by the organism and need to be taken up by nutrition). Tryptophan, phenylalanine, tyrosine, isoleucine, threonine and vali
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br Disclosures br Author contributions
2024-04-09
Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril
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Polycyclic aromatic hydrocarbons PAHs are abundant environme
2024-04-09
Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, enzyme substrate burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs h
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br Therapeutic advantages and clinical implications
2024-04-09
Therapeutic advantages and clinical implications of caffeine treatment in ROP The demonstration of the role of the adenosine receptor in development of ROP and protection by caffeine suggests two potential therapeutic strategies with high translational potential: a) modification of caffeine treat
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Epithelial mesenchymal transition EMT is the process by whic
2024-04-09
Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical TUG-770 receptor cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and repro
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As mentioned above variation of
2024-04-09
As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to saha histone (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having comparable
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Hydroxyzine 2HCl We demonstrate a role for
2024-04-09
We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 Hydroxyzine 2HCl and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRN
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Our previous studies and others have identified
2024-04-09
Our previous studies and others have identified that the inhalational anesthetic isoflurane induces neuronal apoptosis via [Ca2+]i overload through the opening of synaptic voltage-dependent calcium channels (VDCCs) and the excessive Ca2+ release from the endoplasmic reticulum (Zhao et al., 2011; Zh
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br Eprosartan The AT R antagonist eprosartan is approved for
2024-04-08
Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential mmae and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events, independe
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Liaohe River situates in the
2024-04-08
Liaohe River situates in the southwestern part of Northeast China and flows through Liaoning Province. Due to the rapid urbanization and industrialization, Liaohe River has become one of the most polluted rivers in China. Multitudinous organic pollutants that can induce toxicity to organisms such as
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Extracellular ATP and downstream purinergic signaling have a
2024-04-08
Extracellular ATP and downstream purinergic signaling have also been proposed to contribute to dental pulp tissue healing and dentin regeneration. Mechanical and thermal stimulation of external dentin can induce ATP release in dental pulp through pannexins [13]. Cold stimulation was also reported to
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Previous studies have demonstrated the presence of soluble N
2024-04-08
Previous studies have demonstrated the presence of soluble NTPDases, 5′-nucleotidase and adenosine deaminase in rat blood serum as well as in human blood (Doleski et al., 2016; Oses et al., 2004; Yegutkin, 1997; Yegutkin et al., 2007). In addition, our earlier reports have shown that these membrane-
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We also investigated the transmittance of
2024-04-08
We also investigated the transmittance of actin polymerized with and without ABP. The presence of actin in the solution results in an increment in turbidity as other proteins provided LY2157299 features [21], [32]. While G-actin showed a transmittance peak positioned at 241 nm, F-actin exhibited a
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br Experimental Procedures br Acknowledgments br
2024-04-08
Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt
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