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br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia
2021-07-26
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin
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br Fragment based drug discovery
2021-07-26
Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical Silodosin synthesis space with libraries which are smaller in size, producing drug leads with high ligand-binding effici
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In conclusion we developed a new
2021-07-26
In conclusion, we developed a new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model that can be useful for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. In addition, we have shown that the dual CysLT1/2 receptor antagonist ONO-6950 can exert protective effect agai
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br Conclusion In vivo pharmacokinetic
2021-07-26
Conclusion In vivo pharmacokinetic studies showed that dasatinib monohydrate pretreatment significantly decreased the blood level of CsA in rats, which was most probably due to the induction of CYP3A2 isoenzymes. The nilotinib pre-treatment had no significant effects on cyclosporine pharmacokinet
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Introduction Since the recognition of AIDS in
2021-07-26
Introduction Since the recognition of AIDS in 1981 more than thirty-five years ago, nearly 70 million individuals have been infected with human immunodeficiency virus type 1 (HIV) and roughly half have died (http://www.unaids.org/en/resources/documents/2016/AIDS-by-the-numbers). Although the introd
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p kip is a member of the cyclin dependent
2021-07-26
p27kip1 is a member of the cyclin-dependent kinase (CDK) inhibitor family that acts as a potent tumor suppressor in a variety of human cancers and negatively regulates the transition of cells from the G1 to S phase of the cell cycle, protects against inflammatory injury and promotes epithelial diffe
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The desire for COTS products and some potential
2021-07-23
The desire for COTS products––and some potential problems There are also technological reasons in support of the use of OTS products. For example, Dawkins and Riddle (2000) point out that the relatively small safety-related systems market cannot sustain the rate of technological advancement stimula
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Noteworthy the transient downregulation of the regulatory
2021-07-23
Noteworthy, the transient downregulation of the regulatory CK2β subunit reduces HSP27 expression in all the three different human cell lines (Fig. 2b). Similarly, the downregulation of one of the two catalytic subunits, CK2α or CK2α′, is sufficient to affect HSP27 expression without affecting other
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br In order to determine the physiological roles
2021-07-23
In order to determine the physiological roles of WT (wild type) EWSR1, Dr. Lee's group established a conventional Ewsr1 KO mouse [38]. Since then, the Ewsr1 KO (−/−) mouse model has successfully been utilized to decipher many important in vivo roles of EWSR1 (Fig. 1). EWSR1 deficiency alters mi
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The aim of the following
2021-07-23
The aim of the following work was to untap the potential of DIS as a low-cost substrate for fungal production of lignocellulolytic enzymes via SSF. Fungal strains with the ability to transform the unpretreated DIS to a mixture of industrially relevant lignocellulases were identified. Furthermore, t
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HCV has evolved mechanisms to evade humoral immune
2021-07-23
HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 iMDK of the N-terminus of E2, which is referred to as the hypervariable region
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br Discussion The regulation of intracellular cholesterol
2021-07-23
Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec
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Another pathway that requires proper DUB recruitment is the
2021-07-23
Another pathway that requires proper DUB recruitment is the DNA damage response (DDR). After ultraviolet (UV)-induced DNA damage, monoubiquitylated proliferating cell nuclear antigen (PCNA) mediates signaling that leads to repair. The DUB complex USP1/USP1-associated factor 1 (UAF1) deubiquitylates
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br Methods br Results br Discussion Skin biopsy and microneu
2021-07-23
Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific KN-93 organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Liguori,
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br Conclusion The present work describes the synthesis of na
2021-07-23
Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com
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