Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
-
br Transparency document br Main Text The centrosome is
2020-09-25
Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes
-
The homologous DDRs are composed of an N terminal discoidin
2020-09-24
The homologous DDRs are composed of an N-terminal discoidin homology domain, followed by a sequence of ∼220 amino acids unique to the DDRs, a transmembrane domain, a large juxtamembrane domain, and a conserved cytoplasmic tyrosine kinase domain. In a previous study, we demonstrated that DDR activati
-
Closantel Sodium mg Introduction Tumor necrosis factor TNF i
2020-09-24
Introduction Tumor necrosis factor (TNF) is a pro-inflammatory mediator with the capacity to induce apoptosis (Benderska et al., 2012). Recent reports have shown that TNF might trigger cell death, at least in part, by directly affecting the reorganization of the Closantel Sodium mg cytoskeleton (Ca
-
fluvoxamine maleate The levels of circulating pro inflammato
2020-09-24
The levels of circulating pro-inflammatory cytokines are markedly elevated in ESRD, and have been speculated to play an important role as causative factors in a number of uremic complications [37]. The impairment of phagocyte functions and deregulated cytokine productions are highly prevalent in CRF
-
Here we also took attempt
2020-09-24
Here we also took attempt to evaluate the CYP mediated inhibition potential of S. chirata and its biomarker ursolic BB-94 on pooled RLM by CYP-CO complex assay. We observed that S. chirata extract and ursolic acid showed less enzyme inhibition than known inhibitor (ketoconazole). It exhibited less
-
Naringenin is the one of the many components in grapefruit
2020-09-24
Naringenin is the one of the many components in grapefruit juice. It was assumed that administration of 20mL grapefruit juice per kilogram of body weight is completely glucuronidated in the hepatic or gut wall for first pass metabolism [38]. It has been detected that one liter of grapefruit juice co
-
The early serologic response of infants to infection with
2020-09-24
The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV methysergide produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonatal
-
Considering the protumoral functions of
2020-09-24
Considering the protumoral functions of TAMs, new therapies against TAMs have recently gained interest. Such treatments, particularly inhibitors of the colony stimulating factor 1 receptor (CSF-1R), are currently evaluated in several clinical trials [19]. CSF-1R inhibitors may also be of interest in
-
Phylogenetically three related CXC chemokines are classified
2020-09-24
Phylogenetically three related CXC chemokines are classified as the possible ligands for the teleost CXCR1 and CXCR2. They are referred to as CXCL8_L1 (CXCL8/IL-8/CXCa), CXCL8_L2 (CXCc) and CXCL8_L3 (Alejo and Tafalla, 2011, Chen et al., 2013, Laing et al., 2002, Laing and Secombes, 2004, Nomiyama e
-
Phosphorylation of small GTPases has been also
2020-09-24
Phosphorylation of small GTPases has been also observed to affect binding affinity for the GDP/GTP cycle regulators notably GDP dissociation inhibitor (GDI) [10]. Indeed the EGF or cAMP-dependent phosphorylation of Cdc42 is associated with enhanced Cdc42–GDI interaction [8], [11]. RhoA inhibition by
-
Alzheimer s disease AD is
2020-09-24
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder of the Desfuroylceftiofur which is considered a leading cause of dementia and affects 20–30 million people worldwide. Presently, a suitable treatment and prevention strategy against AD is hardly available. Various studies
-
The CLC proteins in Arabidopsis have been studied in
2020-09-24
The CLC proteins in Arabidopsis have been studied in some detail, and a total of seven genes (named AtCLCa-AtCLCg) have been identified (Lv et al., 2009). It is interesting that AtCLCa-AtCLCd and AtCLCg define a distinct phylogenetic branch that is closely related to eukaryotic CLCs, while the other
-
Dose response analysis Fig can be performed on cells
2020-09-24
Dose response analysis (Fig. 2) can be performed on Digoxigenin-11-dUTP in culture, in tissue, in animals or even in patients. Many different responses can be measured, including mRNA levels, reporter gene activity, gene product (e.g. enzyme) activity or even physiological functions such as inhibiti
-
br Materials and methods br
2020-09-23
Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic tetracycline hcl mg induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter s
-
In sum although it is reasonable to
2020-09-23
In sum, although it is reasonable to assume that the activities of an enzyme on alternative (metabolically available) substrates may often depend on neutral drift, the point is difficult to prove because various types of selective pressures can be at play, and these will be different in different or
14083 records 645/939 page Previous Next First page 上5页 641642643644645 下5页 Last page