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NSC228155 br Acknowledgments Authors acknowledge financial s
2020-07-31
Acknowledgments Authors acknowledge financial support from the National Natural Science Foundation of China (31402274, 31172389), the Special Project of Marine Renewable Energy from the State Oceanic Administration (SHME2011SW02), China Postdoctoral Science Foundation (2014M551381) and Shanghai U
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There are several genes and their respective proteins that
2020-07-31
There are several genes and their respective proteins that are involved with CR and a brief description of them follows. Cryptochrome (Cry) is a flavoprotein that acts as a blue light photoreceptor, directly modulating photo-input into the circadian clock. It has been shown that Cry associates with
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Methscopolamine sale The outcome of DGK function will thus
2020-07-30
The outcome of DGK function will thus depend on the binding partners of each DGK isoform, and the effects that they exert can be quite different. A clear example of this concept has been demonstrated for the type IV DGKs, ζ and ι, which are structurally very similar but have opposing effects on Ras
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The binding modes of the compounds were revealed by co
2020-07-30
The binding modes of the compounds were revealed by co-crystal structures with DHODH, determined by X-ray crystallography. The compounds are found at the coenzyme Q site, as expected. -dihydroorotate (DHO), and flavin mononucleotide (FMN) are also observed in the structures which were solved at a re
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br Regulation of DHODH activity in cancer Regulation of
2020-07-30
Regulation of DHODH activity in cancer Regulation of DHODH activity occurs primarily through activation of de novo pyrimidine biosynthesis via the CAD complex. When Sodium 4-Aminosalicylate synthesis are not preparing for growth, flux through the de novo pyrimidine pathway is slow and functions t
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Wide inter individual differences in expression or
2020-07-30
Wide inter-individual differences in Astemizole mg or activity of CYP450 contribute to variations in both clearance and efficacy/toxicity of several drugs. Phenotyping measures provide information on the real-time activities of CYP450 and provide clinically relevant information as they reflect the
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Introduction Cytochrome P CYP A is the most important enzyme
2020-07-30
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The gyy synthesis level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxicity.
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CRM mediates the nuclear export of proteins and messenger
2020-07-30
CRM1 mediates the nuclear export of proteins and messenger RNAs, and is thus an important regulator of the subcellular distribution of key molecules. An increasingly large number of cancer-associated proteins that shuttle into and out of the nucleus, such as tumor suppressor and oncogenic proteins,
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Physiological changes induced by CRF are
2020-07-30
Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,
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br Conclusion In conclusion the current study showed that
2020-07-30
Conclusion In conclusion, the current study showed that central CRF signals have crucial roles in behavioral changes, such as locomotor activity and anxiety behavior. In contrast, the hormonal regulation of CRF through HPA axis can be primarily modulated at the peripheral level. CRF1 receptor ant
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Introduction The inflammation process involves sequential
2020-07-30
Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases Fmoc-Gly-OH were responsible for activation of the production of prostaglandins (PG1s) an
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Streptozocin Since hepatic steatosis and insulin
2020-07-29
Since hepatic steatosis and insulin resistance are often associated, other explanations must account for the relationship. One possibility is that hepatic steatosis, when present, is the result of insulin resistance, possibly because the insulin signaling pathways that drive fatty Streptozocin biosy
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br Acknowledgements The research leading to
2020-07-28
Acknowledgements The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 − Scientia Fellows (JB) and the Research Council of Norway (NFR-grant 221444) (JB, JPM, OB). Introduction Hu
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To test our hypothesis that the relative stability of
2020-07-28
To test our lxr agonists that the relative stability of the DFG-Asp-out conformation is related to promiscuity, we looked at data available in the PKIS2 set for a kinase that was tested in a state stabilized in DFG-Asp-in and the DFG-Asp-out conformation. We found data for activation loop phosphory
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From the same perspective previous studies by Sajdyk
2020-07-28
From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th
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