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The objective of this work
2018-11-12
The objective of this work was to investigate if a synergistic coculture system of MSCs with endothelial Tubastatin A Supplier could affect the number and state of differentiation of harvested MSCs. In contrast to other papers, in this cell-cell communication topic, the investigation was carried out
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The neuroprotective effect of hypoxic
2018-11-12
The neuroprotective effect of hypoxic preconditioning in the sphingosine kinase has been studied by several groups who found evidence for the involvement of HIF-1α and its downstream targets and/or Epo (He et al., 2008) (Liu et al., 2005; Theus et al., 2008) (Prass et al., 2003) (Bernaudin et al.,
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To address the question of whether these HLCs
2018-11-12
To address the question of whether these HLCs could serve in cellular therapies, a variety of markers of hepatocyte differentiation were considered. For example, production of albumin, a classic marker of hepatocyte differentiation, was observed in HLCs (Fig. 2). However, production of albumin has b
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An approach that has shown promise for answering these
2018-11-12
An approach that has shown promise for answering these types of questions in other stem cell systems, and is becoming increasingly feasible with advanced computing power and improved tracking algorithms, is long-term in vitro imaging of individual stem and progenitor cells (Schroeder, 2011). Long-te
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Since the first report of induced
2018-11-12
Since the first report of induced pluripotent stem (iPS) purchase CB-5083 generated by the expression of four transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM) in fibroblasts (Takahashi and Yamanaka, 2006), there has been a variety of technical improvements to generate iPS cells more efficien
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br Materials and methods br Acknowledgements We
2018-11-12
Materials and methods Acknowledgements We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the plasmids. Furthermore, we would like to thank Prof. Duncan R. Smith for proof reading the article. This work was supported by the Thailand Research Fund (MRG5980187), Nat
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Additionally it would be highly
2018-11-12
Additionally, it would be highly desirable to manipulate CSCs to improve their survival and direct them efficiently to the myocyte lineage. A recently developed technology to deliver mRNA in vivo shows promise. Modified RNA (modRNA) encoding human vascular endothelial growth factor-A (VEGF-A) improv
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br Materials and methods br Results br
2018-11-12
Materials and methods Results Discussion It is known that mutation types of SOD1 affect not only enzymatic activity and protein half-life of SOD1, but also age at onset and the survival time of SOD1-ALS patients (Hayward et al., 2002) (Borchelt et al., 1994) (Regal et al., 2006). However, t
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where a is a radius of the circular contact probe
2018-11-09
where a is a radius of the circular contact (probe); r is a distance from the center of the contact – probe place to the hemispherical contact; ρ is a resistivity of the area between the contacts. Spreading resistance R is well approximated for a homogeneous semi-infinite doped sample with resistan
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The C terminal sequence is crucial for maintaining the struc
2018-11-09
The C-terminal sequence 209–223 is crucial for maintaining the structure of the active site, with its deletions leading to loss of the ligand-binding properties [49]. The carboxyl terminus of the first transmembrane domain TM1 is also involved in the formation of the binding site through close inte
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Since the spoken language of the dolphin
2018-11-09
Since the spoken language of the dolphin consists of spectral extrema that act as phonemes, we can hypothesize that it rad51 has both phonological and grammatical structures, so dolphins can create an infinite number of words from a finite number of spectral extrema, which can in turn create an in
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br Conclusion br Acknowledgments br Introduction Studies
2018-11-09
Conclusion Acknowledgments Introduction Studies that extend across multiple life stages promote an understanding of the factors that influence health across the life span (Braveman & Barclay, 2009). A growing literature has examined not only the individual-level socioeconomic factors in ear
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In surveying the literature support for attention biases tow
2018-11-09
In surveying the literature, support for attention biases towards appetitive cues appears in the substance abuse and obesity literatures. For example, attention bias towards drug-related cues has been found among alcohol (Field et al., 2004), tobacco (Bradley et al., 2003; Mogg et al., 2005), caffei
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Gaining knowledge of the temporal dynamics of ensemble
2018-11-09
Gaining knowledge of the temporal dynamics of ensemble perception would be a valuable way to address this issue. For example, our results suggest that ensemble perception could be less rapid as a process in autistic children, due to its greater reliance on some kind of perceptual reasoning. Our stud
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Vitamin D deficiency is associated with
2018-11-09
Vitamin D deficiency is associated with food sensitization (Baek et al., 2014), as well as IgE-mediated food allergy (Allen et al., 2013). Infants from Australian-born parents with vitamin D insufficiency had increased likelihood of egg and peanut allergy (Allen et al., 2013). By contrast, elevated
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