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br Author s Contributions br Funding Sources br Acknowledgem
2018-11-09
Author\'s Contributions Funding Sources Acknowledgements Introduction First isolated in 1947 from the blood of a Rhesus monkey in the Zika forest, Uganda (Dick et al., 1952), Zika virus (ZIKV) was recently declared a global public health emergency by WHO (Heymann et al., 2016). After dec
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It should be pointed out that the
2018-11-09
It should be pointed out that the study reported here has been conducted with a segment of ClfA and it is unclear if Fg binding to the full-length MSCRAMM can involve even more extensive interactions outside the N2N3 sub-domains. Our studies with tefibazumab have also revealed a novel inhibitory mec
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br Conclusions br Conflict of interest br Acknowledgements T
2018-11-09
Conclusions Conflict of interest Acknowledgements This work was supported by National Institutes of Health (R01MH070890-09A1 to JHG); Foundation of Hope for Research and Treatment of Mental Illness Award to WG and UNC-Chapel Hill start-up to WG. We are extremely grateful to the many researc
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When the capacitor was connected to the
2018-11-09
When the capacitor was connected to the Al/phosphate cell via a switch capacitor regulator circuit and was charged from 1.4V to 1.8V, the charging times were 0.51±0.02s and 0.34±0.03s for the single cell and the 2-cell configuration, respectively (Fig. 5). The charge/discharge cycle was observed app
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El n mero de la revista presenta
2018-11-09
El número 394 de la revista presenta aspectos relevantes de la economía en su conjunto, con énfasis en los aspectos coyunturales de mayor preocupación. Así, Jorge Eugenio de Jesus Mora Tordecillas y Mario Camberos Castro nos presentan un panorama acerca del “impacto de las remesas en el gasto regio
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br Introduction Retinal neovascularization is the most
2018-11-09
Introduction Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups; i.e., retinopathy of prematurity (ROP) in children, diabetic retinopathy in adults and age-related macular degeneration in the elderly (Andreoli and Miller, 2007; Chen and Smith,
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Previous studies have demonstrated that
2018-11-08
Previous studies have demonstrated that the effects of stem cell transplantation in animal experiments vary with different times of cell grafting (Chen et al., 2001; Hofstetter et al., 2002). One possible explanation for this may be that the tissue microenvironment at the site of stem cell transplan
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We analyzed whether DLK PREF that
2018-11-08
We analyzed whether DLK1(PREF1), that was firstly identified as a putative marker for murine preadipocytes (Smas and Sul, 1993), could be used as additional marker to characterize human ASC. We found that DLK1(PREF1) is highly expressed in human ASC. The DLK1(PREF1) protein levels were similar in hu
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Currently there is limited information on the stability
2018-11-08
Currently, there is limited information on the stability of the mitochondrial genome during expansion of adult cells. A very limited number of studies have reported the detection of mutations in the mtDNA of human colonic crypt stem sphingosine 1-phosphate receptor modulator as well as in adult and
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The functional roles of SOX in human pluripotency maintenanc
2018-11-08
The functional roles of SOX2 in human pluripotency maintenance and lineage differentiation were recently reported (Wang et al., 2012). SOX2 is not essential for hESC self-renewal. However, overexpression of SOX2 results in the promotion of neural ectodermal differentiation and the suppression of def
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This is in accord with previous reports that astrocytes infl
2018-11-08
This is in accord with previous reports, that astrocytes influence both proliferation and differentiation of embryonic and adult neural stem cells, and specifically promote neurogenic fate of neural stem cells (Roy et al., 2006; Nakayama et al., 2003; Song et al., 2002). Factors that affect neural s
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Importantly using CXCL CXCR interactions as a paradigm for
2018-11-08
Importantly using CXCL12/CXCR4 interactions as a paradigm for other factors and receptors, we demonstrated that CXCL12 is required for chemotaxis, but not chemokinesis of human UCB CD133+ HSPCs in the absence of niche elements, and that the CXCR4 antagonist, AMD3100, inhibits chemokine sensing but n
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We found seven published clinical
2018-11-08
We found seven published clinical trials studying the effects of MSC transplantation in patients with liver cirrhosis (listed in Table 2). A pilot phase 1 study published in 2007 included four patients with decompensated liver cirrhosis (Mohamadnejad et al., 2007). Cells were derived from iliac cres
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br Introduction Developmental myelination and
2018-11-08
Introduction Developmental myelination and myelin repair after demyelination are mediated by oligodendrocyte precursor cells (OPCs). OPCs are characterized by markers such as PDGFRα and the chondroitin sulfate proteoglycan NG2 (Dubois-Dalcq et al., 2008; Franklin and Ffrench-Constant, 2008; Nishi
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ALS is a fatal neurodegenerative disorder
2018-11-08
ALS is a fatal neurodegenerative disorder characterized by a selective and widespread degeneration of lower and upper motor neurons (Gordon, 2013; Rowland and Shneider, 2001). The main symptomatic features of ALS are muscular atrophy, motor paralysis and difficulties in speaking, swallowing, chewing
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