• The PAX gene encodes a transcriptional

  2019-04-26

  

  The PAX5 gene encodes a transcriptional factor, which is specifically expressed at the early stages of B-cell differentiation and it is required for B-cell development. Its dysregulation is involved in the leukemogenesis of B-ALL. The PAX5 gene rearrangements account for approximately 2.5% of pediat

• br Case report The patient was an month old boy

  2019-04-26

  

  Case report The patient was an 11-month-old boy. No abnormalities were observed throughout the embryonic stage and perinatal period. When he was 11 months and 10 day old, he suddenly developed pallor and poor responsiveness, with his eyes rolled back in his head, which continued for approximately

• In contrast to adults PBL in children is regarded

  2019-04-26

  

  In rotenone to adults, PBL in children is regarded as a clinical entity that is distinct from its adult counterpart. Like many other pediatric malignancies, PBL is considered a systemic disease in children. In small retrospective studies, PBL in children is characterized by rapid progression, a hig

• hmg coa reductase Paraguay es puntual en la redacci n del

  2019-04-25

  

  Paraguay es puntual en la redacción del Artículo 8 de su Constitución Nacional cuando dice que “Las actividades susceptibles de producir alteración ambiental serán reguladas por la ley. Asimismo, ésta podrá restringir o prohibir aquéllas que califique peligrosas”. Describe allí las actividades que p

• The Zika virus epidemic is spreading countries are now repor

  2019-04-25

  

  The Zika virus epidemic is spreading: 63 countries are now reporting transmission, over 1500 cases of related microcephaly or CNS malformations have been confirmed this year, and knowledge on the disease is advancing slowly. Adding to the tension around Zika, at the epicentre of the outbreak, Brazil

• In addition to the potential for adverse effects of

  2019-04-25

  

  In addition to the potential for adverse effects of poor growth on brain outcomes in this cohort, the prevalence of iron deficiency was also alarmingly high. All the hospitals recommended iron supplements at discharge and throughout the intervention period, but levels of compliance could not be dete

• Adenosine is an important factor to participate

  2019-04-25

  

  Adenosine is an important factor to participate the generation of ATP. What’s more, adenosine has significant endogenous protective effect such as suppressing the release of excitatory amino acid, reducing the permeability of cell membrane to calcium ion, expanding blood vessel of brain, preventing

• In this study SPR AIRS was

  2019-04-25

  

  In this study, SPR-AIRS was applied to screen p38 ligands from herbal extracts. p38 is an important drug target, which plays a key role in cell proliferation, apoptosis and tumorigenesis [22]. Firstly, recombinant p38 protein was immobilized on SPR chip, the activity and feasibility of the chip was

• br Mega cohort studies Remote monitoring collects a wealth o

  2019-04-25

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• The standard therapy for chordoma is

  2019-04-25

  

  The standard therapy for chordoma is excision. Local recurrence, but not metastasis, is a major determinant of prognosis. Because local recurrence is related to initial surgical margin and intra-operative tumor cell contamination, achieving a safe margin is very important. Boriani [6] reported 153 c

• A type saddle back type or type ST

  2019-04-25

  

  A type 2 (“saddle-back type”) or type 3 ST-segment elevation cannot substitute for a type 1, unless converted to type 1 with fever or sodium drug challenge. A drug challenge–induced type 1 can be used to diagnose BrS only if accompanied by 1 of the criteria specified above. Type 2 is characterized b

• LQT can have numerous clinical manifestations ranging from n

  2019-04-25

  

  LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise

• membrane transport Polymorphic VT VF storms can occur in pat

  2019-04-24

  

  Polymorphic VT/VF storms can occur in patients with severe membrane transport failure, independent of their underlying causes. Recent experimental studies using a pacing-induced heart failure model showed that heart failure facilitates acute shortening of the APD immediately after VF termination [7

• br Conclusions br Study limitations

  2019-04-24

  

  Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum b

• Residing in West Germany also

  2019-04-24

  

  Residing in West Germany also decreased BIS persistence. In 2015, Jacob et al. demonstrated in 4,915 BC women that the treatment discontinuation rate is higher in West Germany than in East Germany [1]. Finally, our study returned one outcome that requires careful discussion: we found that private he

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