As was shown in this study along with many other

2018-10-20

As was shown in this study, along with many other previous studies, TALEN and double-nicking CRISPR/Cas9 genome-editing techniques are significantly accurate, with only a negligible risk of random gene disruption, in the drug-selected clones. This result indicates that disrupting a particular gene w

Heat shock proteins as molecular chaperones are involved

2018-10-20

Heat shock proteins, as molecular chaperones, are involved in a variety of cellular functions. Apart from their commonly known roles in maintaining protein stability and mediating the assembly and disassembly of protein complexes, recent studies have shown that certain chaperones, including HSPA8, a

Neurogenesis in the adult mammalian brain occurs

2018-10-20

Neurogenesis in the adult mammalian Avasimibe occurs throughout life and has been clearly demonstrated at two locations under physiological conditions: the SVZ of the lateral ventricle and the subgranular zone (SGZ) of the DG in the hippocampus (Alvarez-Buylla and Lim, 2004). Several studies have s

In summary our results revealed

2018-10-20

In summary, our results revealed that loss of Eva1a leads to impaired NSC self-renewal and differentiation, along with a decrease in autophagy, which is inversely associated with the activation of the PIK3CA/AKT-mTOR signaling. Functionally, EVA1A overexpression or MP treatment substantially rescued

Transplantation of RPE cells may

2018-10-20

Transplantation of RPE cells may be a treatment for retinal diseases, such as age-related macular degeneration (AMD). Many experimental clinical applications of allogeneic RPE cells for the treatment of AMD have been attempted (Algvere, 1997; Algvere et al., 1999; Kaplan et al., 1999; Peyman et al.,

Hello world!

2018-07-29