• This is in accord with previous reports that astrocytes infl

  2018-11-08

  

  This is in accord with previous reports, that astrocytes influence both proliferation and differentiation of embryonic and adult neural stem cells, and specifically promote neurogenic fate of neural stem cells (Roy et al., 2006; Nakayama et al., 2003; Song et al., 2002). Factors that affect neural s

• Importantly using CXCL CXCR interactions as a paradigm for

  2018-11-08

  

  Importantly using CXCL12/CXCR4 interactions as a paradigm for other factors and receptors, we demonstrated that CXCL12 is required for chemotaxis, but not chemokinesis of human UCB CD133+ HSPCs in the absence of niche elements, and that the CXCR4 antagonist, AMD3100, inhibits chemokine sensing but n

• We found seven published clinical

  2018-11-08

  

  We found seven published clinical trials studying the effects of MSC transplantation in patients with liver cirrhosis (listed in Table 2). A pilot phase 1 study published in 2007 included four patients with decompensated liver cirrhosis (Mohamadnejad et al., 2007). Cells were derived from iliac cres

• br Introduction Developmental myelination and

  2018-11-08

  

  Introduction Developmental myelination and myelin repair after demyelination are mediated by oligodendrocyte precursor cells (OPCs). OPCs are characterized by markers such as PDGFRα and the chondroitin sulfate proteoglycan NG2 (Dubois-Dalcq et al., 2008; Franklin and Ffrench-Constant, 2008; Nishi

• ALS is a fatal neurodegenerative disorder

  2018-11-08

  

  ALS is a fatal neurodegenerative disorder characterized by a selective and widespread degeneration of lower and upper motor neurons (Gordon, 2013; Rowland and Shneider, 2001). The main symptomatic features of ALS are muscular atrophy, motor paralysis and difficulties in speaking, swallowing, chewing

• The following is the supplementary data

  2018-11-08

  

  The following is the supplementary data related to this article. Authors\' contributions O.F. contributed to prepare experimental design, performed Ca measurements, helped with data and statistical analysis, immunocytochemistry, confocal imaging, and contributed in manuscript writing. Disclos

• retinoid x receptor By qPCR we confirmed that

  2018-11-08

  

  By qPCR we confirmed that DLL4 mRNA levels increase dramatically as the control shSCR cells undergo differentiation, but in shDLL4 cells the DLL4 mRNA is efficiently suppressed (Fig. 2E, left panel). To confirm that DLL4 mRNA suppression had a functional effect we analyzed the mRNA levels of two wel

• br Conclusion Cellular reprogramming is an inefficient proce

  2018-11-08

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor URMC-0

• The transgenic iPSCs differentiate into embryoid

  2018-11-08

  

  The transgenic iPSCs differentiate into embryoid bodies (EBs) containing spontaneously beating EGFP-positive areas, which first appear on day 7–9 of differentiation (Fig. 2A). After 7days of puromycin treatment, nearly all non-cardiomyocytes in EBs are eliminated and the resistant Madecassoside sur

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Induced pluripotent stem Q-VD-Oph (iPSCs) can be generated by introducing OCT4, SOX2, KLF4, and c-MYC (Takahashi et al., 2007; Takahashi and Yamanaka, 2006) or other combinations of reprogramming factors (Stadtfeld and Hochedlinger, 2010)

• buy TCEP br Materials and methods br Acknowledgments We

  2018-11-08

  

  Materials and methods Acknowledgments We would like to thank Dr. Saran Karumbayaram for providing guidance in the culture and expansion of the primate fibroblasts. We would also like to thank Steven Dowdy for depositing the T7-VEE-OKS-iG plasmid (Addgene). This project was funded by NIH grant

• Since hiPSC CMs can mature in vitro over time

  2018-11-08

  

  Since hiPSC-CMs can mature in vitro over time in culture (Lundy et al., 2013), they may prove valuable for investigating the developmental time course of early-stage cardiac diseases, representing a unique platform to predict adverse prenatal outcomes and to develop therapies. We reported FCM hiPSC-

• The Mx Cre system can be potentially associated

  2018-11-08

  

  The Mx1-Cre system can be potentially associated with additional problems. For instance, pIpC administration has been suggested to trigger HSC cycling, similar to interferon itself (Essers et al., 2009; Gidali et al., 1981; Sugiyama et al., 2006). While we found less evidence for a dramatic effect o

• We then assessed the three labeled populations At day

  2018-11-07

  

  We then assessed the three labeled populations. At day 4 after 4-OHT treatment, Osx+, ++, and Ocn+ order Cisplatin were purified by fluorescence-activated cell sorting from bone cell suspensions isolated from the triple transgenic model, and subjected to gene-expression profiling by microarray. Pri

• Introduction One of the key drivers of

  2018-11-07

  

  Introduction One of the key drivers of performance of salespeople was long ago speculated to be ego-drive (Mayer & Greenberg, 1964). Ego-drive has not been studied systematically in marketing and has been defined in various ways, referring to motivation, a “need to conquer”, and pride. We attempt i

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