• br Conclusion br Introduction br CRL E ligases in

  2019-09-25

  

  Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank th

• Poxviruses have double stranded DNA dsDNA genomes yet they r

  2019-09-25

  

  Poxviruses have double-stranded DNA (dsDNA) genomes, yet they replicate within the cytoplasm. Poxviruses that cause human disease include monkeypox virus (Reynolds et al., 2004), molluscum contagiosum virus (Hanson and Diven, 2003) and variola virus (VARV), the cause of smallpox, a disease eradicate

• Our previous work has demonstrated that two glutamate residu

  2019-09-24

  

  Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17]. At least one of these, Glu-331, seems to form a salt bridge to the N-terminal amino group of the substrate, posi

• Perturbation in the cytokine network is correlated with disr

  2019-09-24

  

  Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg

• Resveratrol is a phytoalexin that occurs in relatively large

  2019-09-24

  

  Resveratrol is a phytoalexin that occurs in relatively large amounts in peanut, berries, grapes, and red wine (Soleas et al., 2001). A recent study showed that resveratrol prevents social deficit in an animal model of autism, indicating its potential for possible therapeutic use in children with aut

• Studies have shown that the cultivation of

  2019-09-24

  

  Studies have shown that the cultivation of BMSCs under hypoxic conditions, treating with cytokines (such as HGF, IGF-1 and IL-6) and viral-mediated CXCR-4 gene delivery have been shown to re-establish CXCR-4 expression on the surface of stem q vd oph (Liu et al., 2010, Liu et al., 2014a, Ziaei et a

• Beside the previously reported Topo I inhibition

  2019-09-24

  

  Beside the previously reported Topo I inhibition, time and concentration dependent CRM1 inhibitory properties of klavuzon derivatives have been shown as a second mechanism of action in this work. Especially, compounds 3 and 20 are the most effective derivatives and they completely inhibit CRM1 activ

• Social interaction is known to be

  2019-09-24

  

  Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005). An animal model of social stress should closely mimic real-life situations in human life (Neisewander et al., 2012); in this context, social defeat in an agonistic encoun

• br Experimental br Results and discussion Fig shows schemati

  2019-09-24

  

  Experimental Results and discussion Fig. 2 shows schematically the fundamentals of the developed HRP-P4-(P4)-anti-P4-Protein-G-MBs/SPCE immunosensor. Oriented immobilization of anti-P4 was accomplished onto Protein G-MBs due to the Protein G binding ability with the Fc region of many mammals i

• An increased CK activity was found in septal

  2019-09-24

  

  An increased CK2 activity was found in septal neuronal order ridaforolimus dissected from rat embryos after hypoglycemia [36]. These data indicated that CK2 activity is not only regulated by insulin but also by the glucose concentration. One essential step in insulin action is the binding of the h

• br Conflict of interest br

  2019-09-24

  

  Conflict of interest Acknowledgements This study was supported by the National Natural Science Foundation of China (No.31571839), the Chinese Ministry Program for New Century Excellent Talents in University (NCET-12-0865), and Special Fund for Agro-scientific Research in the Public Interest (N

• Not all of the biological activities exhibited by

  2019-09-24

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the tlr inhibitor is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to respo

• cAMP mediated signaling pathways are important for maintaini

  2019-09-24

  

  cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, Belinostat kinase of the PKA 2β regulatory subunit (RIIβ) in mice leads to increased expres

• br Conclusion The past few years have witnessed

  2019-09-24

  

  Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte

• br RING type E s and their substrates There is

  2019-09-24

  

  RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult

16479 records 989/1099 page Previous Next First page 上5页 986987988989990 下5页 Last page