• FPH1 (BRD-6125): Redefining Hepatocyte Expansion for Regener

  2026-07-20

  Explore how FPH1 (BRD-6125) advances primary human hepatocyte proliferation and functional maturation. This article reveals unique mechanisms and assay implications for hepatocyte culture, bridging optogenetic gene therapy advances with next-generation liver research.

• Mechanisms of Spiroplasma eriocheiris Entry in Drosophila S2

  2026-07-20

  This study demonstrates that Spiroplasma eriocheiris invades Drosophila S2 cells primarily through clathrin-mediated endocytosis and macropinocytosis. The research highlights the critical role of cytoskeletal elements, particularly microtubules and actin filaments, in the infection process, providing new insights for host-pathogen interaction studies and microtubule dynamics research.

• HyperScribe™ T7 High Yield Cy3 RNA Labeling Kit Plus: Practi

  2026-07-19

  The HyperScribe™ T7 High Yield Cy3 RNA Labeling Kit Plus addresses the technical need for high-yield, randomly Cy3-labeled RNA probe synthesis for applications requiring sensitive fluorescent detection, such as in situ hybridization and Northern blotting. It is intended strictly for research workflows and is not validated for diagnostic or therapeutic purposes.

• Auranofin: Precision Thioredoxin Reductase Inhibitor for Red

  2026-07-18

  Auranofin is a highly selective thioredoxin reductase inhibitor that enables robust modulation of cellular redox homeostasis. It demonstrates potent apoptosis induction and radiosensitizing effects in tumor models, making it a pivotal tool for cancer research and oxidative stress studies.

• Cefazedone (Refosporen): Precision PK Profiling & In Vitro O

  2026-07-17

  Explore the pharmacokinetic precision and advanced in vitro applications of Cefazedone (Refosporen), a first-generation cephalosporin. This article uniquely bridges assay optimization, PK/PD integration, and resistance management for modern antibacterial research.

• Açaí Extracts in Human Hepatocytes: Cytotoxicity and Enzyme

  2026-07-17

  This study delivers the first systematic evaluation of açaí (Euterpe oleracea) extracts for cytotoxicity and modulation of key drug-metabolizing enzymes and transporters in human hepatocytes. The findings reveal dose- and time-dependent cytotoxicity for select extracts but minimal potential for enzyme or transporter induction, providing critical insights for predicting botanical-drug interaction risks.

• A Multi-Organ Endodermal Atlas Benchmarks Human Organoid Mod

  2026-07-16

  Yu et al. (2021) present a single-cell transcriptomic atlas of developing human endodermal organs, enabling unprecedented benchmarking of stem cell-derived intestinal organoids. This work refines our understanding of cell state transitions and niche cues in human development, offering new standards for in vitro model fidelity.

• Prednisolone in Glucocorticoid Signaling and ERAD-Assisted P

  2026-07-16

  Prednisolone is a synthetic glucocorticoid trusted for dissecting immune and inflammation pathways, now central to advanced workflows exploiting ER-associated degradation (ERAD) for targeted membrane protein modulation. This article explores hands-on protocol enhancements, troubleshooting strategies, and the scientific edge Prednisolone offers in the evolving landscape of glucocorticoid signaling and protein degradation research.

• FPH1 (BRD-6125): Advancing Functional Human Hepatocyte Expan

  2026-07-15

  Discover how FPH1 (BRD-6125) enables robust, donor-independent expansion of primary human hepatocytes for advanced research. This deep dive explores its mechanism, protocols, and integration with optogenetic gene regulation, offering new insights beyond standard assay guides.

• Repurposing Natural Compounds for SARS-CoV-2 Protease Inhibi

  2026-07-15

  Eskandari et al. (2022) identified several natural vitamins with strong in silico binding affinity to SARS-CoV-2 main protease (3CLpro) and spike protein RBD, highlighting their potential as accessible antiviral agents. The study's molecular docking and dynamics approaches provide technical foundations for further drug discovery and assay development targeting COVID-19.

• Biomimetic Chromatography for Modeling Pulmonary Drug Permea

  2026-07-14

  The reference study systematically compares immobilised artificial membrane liquid chromatography (IAM LC) and liposome electrokinetic capillary chromatography (LEKC) for predicting drug permeability across the respiratory mucosa. By benchmarking 26 diverse compounds, the research highlights LEKC’s superior ability to simulate pulmonary membrane interactions, while also outlining the practical trade-offs between these two biomimetic techniques for respiratory drug development.

• Efficient Synthesis of Deuterium-Labeled Degarelix Acetate

  2026-07-14

  This study presents a robust method for synthesizing deuterium-labeled degarelix acetate, a third-generation GnRH receptor antagonist integral to prostate cancer research. The approach enables the production of stable isotope-labeled internal standards, advancing clinical pharmacokinetic and hormone regulation studies.

• 7-Ethyl-10-hydroxycamptothecin: Dual Mechanisms in Colon Can

  2026-07-13

  7-Ethyl-10-hydroxycamptothecin, also known as SN-38, is a potent DNA topoisomerase I inhibitor and apoptosis inducer in colon cancer cells. It demonstrates cell cycle arrest in S and G2 phases and uniquely disrupts FUBP1–DNA binding, expanding its utility in advanced colon cancer research.

• Danazol in Endocrine Models: Protocols, Use-Cases & Troubles

  2026-07-13

  Danazol (Danocrine) is indispensable for modeling steroidogenesis inhibition and HPG axis modulation, enabling robust studies of precocious puberty and prostate cancer. This guide delivers stepwise workflows, actionable troubleshooting, and a synthesis of the latest reference advances for reproducible, high-impact research.

• Modified Degarelix Analogs: Stereochemistry and GnRH Antagon

  2026-07-12

  This study explores the effects of stereospecific modification at position 3 of Degarelix, a potent GnRH receptor antagonist, using 3-(2-methoxy-5-pyridyl)-alanine. The research reveals key structure-activity relationships that inform future design of peptide-based antagonists for hormone-dependent cancer therapy.

16757 records 1/1118 page Next 12345 下5页 Last page